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When toxins accumulate further, active glutathione continues to decrease

Megaloblastic anemia due to B12 deficiency is either caused by inadequate intake, in which case oral supplementation is sufficient, or poor absorption potentially due to a reduction in intrinsic factor. Intrinsic factor, which is synthesized by cells in the stomach, is secreted into the gastrointestinal tract to bind dietary B12 and facilitate its absorption (Wickramasinghe 2006)

Without food interference, glutathione molecules move directly into your intestinal cells

Alcohol and its breakdown products affect liver genes and DNA

doi: 10.1038/mi.2008.53 99 AndresenL

& Sonenberg, N